Since the early 1990s much progress has been made in developing dengue vaccines. The most advanced candidates include the following approaches:
- Live attenuated vaccines, prepared through advanced genetic techniques, including chimerization or sequence deletion.
- Purified inactivated vaccines.
- Subunit vaccines, which use a portion of the envelope protein of dengue virus.
Other vaccines still in pre-clinical phases of development include plasmid DNA and vectored approaches.