October 25, 2013
Cooperation Among Early Adopter Countries for Dengue Vaccines

This meeting gathered together representatives from the Ministries of Health (MOH) and National Regulatory Authorities (NRA) of early adopter countries of a dengue vaccine.

Overview of Dengue Vaccines


Since the early 1990s much progress has been made in developing dengue vaccines.  The most advanced candidates include the following approaches:

  • Live attenuated vaccines, prepared through advanced genetic techniques, including chimerization or sequence deletion.
  • Purified inactivated vaccines.
  • Subunit vaccines, which use a portion of the envelope protein of dengue virus.

Other vaccines still in pre-clinical phases of development include plasmid DNA and vectored approaches.